![]() “Most side effects last 24–48 hours,” says Dr. “The immune system is complex, and the vaccine is still working even if you don’t feel it.” How long will the side effects from the shot most likely last?ĭata from the University of Alabama at Birmingham notes that mRNA vaccines, like the COVID shot, deliver their payload and then quickly leave your body, so this eliminates the concern of any long-term side effects. “You don’t need to worry if you’re one of the lucky ones that doesn’t have side effects,” adds Dr. Still, fewer side effects, less severe ones or a lack of any side effects doesn’t mean you're not well-protected – it simply shows that your bodies are different. However, everyone’s immune system is unique to them, and responds uniquely when presented with something foreign from a vaccine.”Īs the research shows, side effects may indicate your system got a nice boost against COVID. “Side effects are related to your immune system recognizing the antigen or foreign protein in the vaccine and responding. Although most people experience one or two side effects, “there are some people who don’t have any,” she says. If you don’t have side effects, you can still rely on the vaccine’s effectiveness, says Judith O’Donnell, MD, professor of infectious diseases at the Perelman School of Medicine at the University of Pennsylvania and section chief of infectious diseases at Penn Presbyterian Medical Center in Philadelphia. But I don't have any side effects, is the vaccine still working?
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